The Memphis Tigers will host the Rice Owls at Simmons Bank Liberty Stadium in Memphis on Friday, November 8, 2025, at 9:00 p.m. ET. Memphis is coming off a tough 44-36 loss to UTSA that effectively dashed their College Football Playoff (CFP) hopes. With their attention now focused on securing an American Athletic Conference (AAC) title, the Tigers face a challenging test against a resilient Rice team. The Owls, fresh off an upset victory over Navy, have proven they can hang with some of the top teams in the conference and are looking to throw a wrench in Memphis’ title aspirations.
Rice vs Memphis Predictions 2025
Rice enters the game as a 9.5-point underdog, but their top-tier defense, which ranks 23rd in the nation in total yards allowed, gives them a legitimate chance to make it a close contest. Memphis’ potent offense, led by quarterback Seth Henigan, will face a stiff challenge in trying to break through Rice’s stout pass defense, which ranks among the best in the AAC. Despite recent struggles, the Tigers have the edge in talent, but this emotional letdown game could give the Owls an opening to pull off another upset. Here’s a breakdown of key details and predictions for the Rice vs. Memphis matchup, along with betting trends and analysis.