The Oklahoma Sooners (5-4) will visit Memorial Stadium in Columbia, Missouri, to take on the Missouri Tigers (6-2) on Saturday, November 9, 2025. With the game slated to kick off at 7:45 p.m. ET, this SEC showdown presents an intriguing matchup. Missouri enters the game as 3-point underdogs, with a total of 41.5 points set for the over/under. Oklahoma is coming off a dominant 59-14 win over the Maine Black Bears, while Missouri suffered a tough 34-0 loss to the Alabama Crimson Tide in their last outing.
Oklahoma vs. Missouri 2025
As both teams look to stay competitive in their respective conferences, the Sooners are favorites to win, according to the latest odds. However, Missouri has the home advantage and a defense ranked 14th nationally in points allowed per game. Oklahoma’s offense, led by quarterback Jackson Arnold, will look to take advantage of Missouri’s defense, while the Tigers will need to rebound from their recent defeat and get their offense, including quarterback Brady Cook, back on track.